| Title | [Histomorphologic and respiratory aspects of acute lung injury in rats induced by experimental sepsis and under pentoxifylline treatment.] | | Author(s) | Oliveira WR, Cavassani SS, Maganhin CC, Carbonel AA, Simões MJ, Simões RS, Junqueira VB, Oliveira-Júnior IS | | Institution | Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP. | | Source | Rev Assoc Med Bras 2009 Mar-Apr; 55(2):127-31. | | Abstract | OBJECTIVE: Respiratory repercussion on acute lung injury in a model of induced sepsis intraperitoneally.
METHODS: Fifteen animals taken at random were submitted to adult male Wistar rats. The rats were randomly divided into 3 groups (n=15): Group C - control group received only mechanical ventilation; Group S - rats received live Escherichia coli (E. coli) intraperitoneally (septic) and after 6 hours they were treated with normal saline infusion and ventilated with a low tidal volume. Group S+PTX - rats received live Escherichia coli intraperitoneally (septic) and after 6 hours they were treated with pentoxifylline (PTX) infusion and ventilated with a low tidal volume. All animals were ventilated during 180 minutes. We analyzed the arterial blood gases, gravimetric indices and histomorphometric analysis.
RESULTS: Blood gases, wet to dry ratios, and total protein concentrations in the bronchoalveolar lavage were analyzed in all experimental groups. In the end of the experiment the partial pressure of oxygen was higher in the GS+PTX (460,0 +/- 38,2 mmHg) compared with GS (336,0 +/- 14,6 mmHg). Pentoxifylline with low tidal volume attenuated significantly total protein in the bronchoalveolar lavage. The septal diameter was significantly reduced in the group GS compared with group GS+PTX (P < 0,05).
CONCLUSIONS:The pentoxifylline ameliorated the oxygenation and decreased the deleterious effects of sepsis in the associated mechanical ventilation. | | Language | por | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19488645 |
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